FU19 Nephrops Grounds 2022 UWTV Survey Report and catch scenarios for 2023

This report provides the main results of the twelfth underwater television survey of the various Nephrops patches in Functional Unit 19. The survey was multi-disciplinary in nature collecting UWTV and other ecosystem data. In 2022 a total 42 UWTV stations were successfully completed. The mean density estimates varied considerably across the different patches. The 2022 raised abundance estimate showed a 4% decrease from the 2021 estimate and at 259 million burrows is below the MSY Btrigger reference point (430 million). Using the 2022 estimate of abundance and updated stock data implies catch in 2023 that correspond to the F ranges in the EU multi annual plan for Western Waters are between 302 and 338 tonnes (assuming that discard rates and fishery selection patterns do not change from the average of 2019–2021). One species of sea pen was observed; Virgularia mirabilis which has been observed on previous surveys of FU19. Trawl marks were observed at 12% of the stations surveyed

The Labadie, Jones and Cockburn Banks Nephrops Grounds (FU2021) 2022 UWTV Survey Report and catch scenarios for 2023

This report is embargoed unti the 1st November when it will be published in sync with ICES.This report provides the main results of the 2022 underwater television survey on the ‘Labadie, Jones and Cockburn Banks’ ICES assessment area; Functional Unit 2021. The 2022 annual survey was multi-disciplinary in nature collecting UWTV and other ecosystem data. A total of 92 UWTV stations were completed at 6 nm intervals over a randomised isometric grid design. The mean burrow density was 0.10 burrows/m2 compared with 0.12 burrows/m2 in the year 2021. The 2022 geostatistical abundance estimate was 1032 million, a 14% decrease on the abundance from 2021, with a CV of 5%, which is well below the upper limit of 20% recommended by SGNEPS 2012. Low to medium densities were observed throughout the ground. Using the 2022 estimate of abundance and updated stock data implies catch in 2023 that correspond to the ICES MSY approach of 1803 tonnes assuming that discard rates and fishery selection patterns do not change from the average of 2019–2021. One species of sea-pen (Virgularia mirabilis) was recorded as present at the stations surveyed. Trawl marks were observed at 20% of the stations surveyed

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing

Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound competent latent and transcriptionally active reservoir cells persevere despite antiretroviral therapy and rekindle infection due to inefficient proviral silencing. We propose a novel “block-lock-stop” approach, entailing long term durable silencing of viral expression towards an irreversible transcriptionally inactive latent provirus to achieve long term antiretroviral free control of the virus. A graded transformation of remnant HIV-1 in PLWH from persistent into silent to permanently defective proviruses is proposed, emulating and accelerating the natural path that human endogenous retroviruses (HERVs) take over millions of years. This hypothesis was based on research into delineating the mechanisms of HIV-1 latency, lessons from latency reversing agents and advances of Tat inhibitors, as well as expertise in the biology of HERVs. Insights from elite controllers and the availability of advanced genome engineering technologies for the direct excision of remnant virus set the stage for a rapid path to an HIV-1 cure